Abstract
Dopamine synthesized in non-neural tissues, eg, renal proximal tubule, functions in an autocrine or paracrine manner. The effects of dopamine are transduced by two classes of receptors (D1- and D2-like) that belong to the superfamily of G protein-coupled receptors. In genetic hypertension, the D1 receptor, a member of the D1-like receptor family, is uncoupled from its G protein complex, resulting in a decreased ability to regulate renal sodium transport. The impaired D1 receptor/G protein coupling in renal proximal tubules in genetic hypertension is secondary to abnormal phosphorylation and desensitization of the D1 receptor caused by activating single nucleotide polymorphisms of a G protein-coupled receptor kinase, GRK type 4.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
G-Protein-Coupled Receptor Kinase 4
-
GTP-Binding Proteins / genetics
-
GTP-Binding Proteins / metabolism
-
GTP-Binding Proteins / physiology
-
Humans
-
Hypertension / enzymology
-
Hypertension / genetics*
-
Hypertension / metabolism
-
Hypertension / physiopathology*
-
Protein Serine-Threonine Kinases / genetics
-
Protein Serine-Threonine Kinases / metabolism
-
Protein Serine-Threonine Kinases / physiology
-
RGS Proteins / genetics
-
RGS Proteins / metabolism
-
RGS Proteins / physiology
-
Receptors, Dopamine / genetics
-
Receptors, Dopamine / metabolism
-
Receptors, Dopamine / physiology*
-
Signal Transduction / genetics
Substances
-
RGS Proteins
-
Receptors, Dopamine
-
Protein Serine-Threonine Kinases
-
G-Protein-Coupled Receptor Kinase 4
-
GRK4 protein, human
-
GTP-Binding Proteins