Abstract
Several experimental strategies have been employed to minimize tissue damage and to enhance axonal growth and regeneration after spinal cord injury. The transplantation of suitable cell types to provide an axonal growth substrate and the application of growth factors have been shown to augment morphological and sometimes functional recovery. In this review we discuss the use of neural stem cell transplants and neurotrophic factor delivery by gene therapy to improve axonal regeneration in animal models of spinal cord injury.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Brain Tissue Transplantation / methods*
-
Brain Tissue Transplantation / trends*
-
Genetic Therapy / methods*
-
Genetic Therapy / trends*
-
Humans
-
Nerve Growth Factors / genetics
-
Nerve Growth Factors / metabolism
-
Nerve Growth Factors / therapeutic use*
-
Nerve Regeneration / physiology*
-
Neurons / cytology
-
Neurons / metabolism
-
Neurons / transplantation*
-
Spinal Cord Injuries / metabolism
-
Spinal Cord Injuries / physiopathology
-
Spinal Cord Injuries / therapy*
-
Stem Cell Transplantation*
-
Stem Cells / cytology
-
Stem Cells / metabolism