Abstract
A methylenetetrahydrofolate reductase polymorphism (677 C/T mutation) was recently implicated in the etiology of Down syndrome. We studied a cohort of 85 women carrying fetuses with Down syndrome and found no difference in the frequencies of the three groups of subjects (C/C, C/T, T/T) between Down syndrome mothers and controls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Down Syndrome / etiology*
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Down Syndrome / genetics*
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Female
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Heterozygote
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Homozygote
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Humans
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Male
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Methylenetetrahydrofolate Reductase (NADPH2)
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Middle Aged
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Oxidoreductases Acting on CH-NH Group Donors / genetics*
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Polymorphism, Genetic*
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Pregnancy
Substances
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Oxidoreductases Acting on CH-NH Group Donors
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Methylenetetrahydrofolate Reductase (NADPH2)