Abstract
Interleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons.
MeSH terms
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Adult
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Disease Susceptibility
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Female
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HLA-DR2 Antigen / immunology
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Humans
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Interleukin-10 / biosynthesis
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Interleukin-10 / genetics*
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Male
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Middle Aged
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Multiple Sclerosis, Chronic Progressive / genetics*
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Multiple Sclerosis, Chronic Progressive / immunology
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Multiple Sclerosis, Relapsing-Remitting / genetics*
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Multiple Sclerosis, Relapsing-Remitting / immunology
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Polymorphism, Genetic*
Substances
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HLA-DR2 Antigen
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Interleukin-10