The anaphase-promoting complex: proteolysis in mitosis and beyond

Mol Cell. 2002 May;9(5):931-43. doi: 10.1016/s1097-2765(02)00540-3.

Abstract

Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins and thereby targets them for destruction by the 26S proteasome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cell Cycle Proteins / metabolism
  • Cyclins / physiology
  • Endopeptidases*
  • Ligases / physiology*
  • Mitosis / physiology*
  • Peptide Hydrolases / metabolism
  • Proteasome Endopeptidase Complex*
  • Separase
  • Signal Transduction
  • Transforming Growth Factor beta / physiology
  • Ubiquitin-Protein Ligase Complexes*
  • Ubiquitins / metabolism

Substances

  • Cell Cycle Proteins
  • Cyclins
  • Transforming Growth Factor beta
  • Ubiquitins
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Endopeptidases
  • Peptide Hydrolases
  • Separase
  • Proteasome Endopeptidase Complex
  • ATP dependent 26S protease
  • Ligases