A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas

Cytogenet Cell Genet. 2001;95(3-4):153-6. doi: 10.1159/000059338.

Abstract

The lipoma preferred partner (LPP) gene is fused to the high mobility group protein gene HMGIC in lipomas and pulmonary chondroid hamartomas. In addition, a fusion of LPP to the mixed lineage leukemia (MLL) gene has been described in a case of acute myeloid leukemia. Herein, a novel LPP fusion transcript of LPP in a lipoma is described that points to the possible oncogenic potential of LPP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Base Sequence
  • Cytoskeletal Proteins / genetics*
  • Female
  • Hamartoma / genetics*
  • High Mobility Group Proteins / genetics*
  • Humans
  • LIM Domain Proteins
  • Lipoma / genetics*
  • Lung Neoplasms / genetics*
  • Molecular Sequence Data
  • Oncogene Proteins, Fusion
  • RNA Splice Sites / genetics

Substances

  • Cytoskeletal Proteins
  • High Mobility Group Proteins
  • LIM Domain Proteins
  • LPP protein, human
  • Oncogene Proteins, Fusion
  • RNA Splice Sites