Genetic polymorphisms of cytochrome P450 1A1 and risk of gallbladder cancer

J Exp Clin Cancer Res. 2002 Mar;21(1):119-24.

Abstract

The relation between cytochrome P4501A1 (CYP1A1) gene polymorphisms and the risk of gallbladder cancer was examined. To clarify individual differences in susceptibility to gallbladder carcinogenesis, we investigated the frequency of the Mspl and Ile-Val polymorphisms of the CYP1A1 gene, in 52 patients with gallbladder cancer (32 females, 20 males) and 104 healthy controls (64 females, 40 males). We then examined the relationship between the CYP1A1 polymorphisms and the development of gallbladder cancer in members of both sexes. A statistical difference in the frequencies of the MspI and Ile-Val polymorphisms or their alleles (ml, m2 and Ile, Val) was not observed in the male patients and controls. Among females, however, the frequencies of genotypes C and Ile/Val were significantly higher (p < 0.05) in the patients than in their controls. Moreover, the frequency of the hetero genotype Ile/Val was statistically higher (p < 0.05) in the female patients than in the male patients. This study demonstrated a significant over-representation of genotypes C and Ile/Val in female patients with gallbladder cancer. Females with genotypes C and/or Ile/Val may have a high genetic susceptibility to the development of gallbladder cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Case-Control Studies
  • Cytochrome P-450 CYP1A1 / chemistry
  • Cytochrome P-450 CYP1A1 / genetics*
  • DNA Primers / chemistry
  • DNA, Neoplasm / metabolism
  • Female
  • Gallbladder Neoplasms / enzymology
  • Gallbladder Neoplasms / genetics*
  • Genotype
  • Humans
  • Incidence
  • Isoleucine / chemistry
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Risk Factors
  • Valine / chemistry

Substances

  • DNA Primers
  • DNA, Neoplasm
  • Isoleucine
  • Cytochrome P-450 CYP1A1
  • Valine