IGF2 genotype and obesity in men and women across the adult age span

Int J Obes Relat Metab Disord. 2002 Apr;26(4):585-7. doi: 10.1038/sj.ijo.0801927.

Abstract

We studied a previously reported association between the IGF2 gene's ApaI polymorphism and obesity in 500 healthy men and women (19-90 y). We hypothesized that individuals homozygous for the IGF2 A allele (A/A) would exhibit lower body mass, BMI and DEXA-measured fat mass compared to G/G homozygotes. Subjects were categorized as exhibiting the G/G (n = 241), G/A (n = 197) or A/A (n = 62) genotype. Contrary to our hypothesis, no difference was observed in body mass, body mass index (BMI) or fat mass between the G/G and A/A genotype groups in the entire cohort. Surprisingly, Caucasian A/A individuals (n = 427) exhibited significantly higher fat mass compared to Caucasian G/G individuals (P < 0.05). In summary, individuals homozygous for the IGF2 G allele do not exhibit higher body mass, BMI or fat mass compared to A/A individuals; however, Caucasians with the A/A genotype exhibit higher fat mass than G/G individuals.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adipose Tissue
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Body Composition
  • Body Mass Index
  • Female
  • Genotype
  • Homozygote
  • Humans
  • Insulin-Like Growth Factor II / analysis
  • Insulin-Like Growth Factor II / genetics*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Obesity / epidemiology*
  • Obesity / genetics*

Substances

  • Insulin-Like Growth Factor II