Abstract
Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development.
Copyright 2002 Cancer Research UK
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA Primers / chemistry
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Glypicans
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Heparan Sulfate Proteoglycans / genetics*
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Humans
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Kidney Neoplasms / genetics*
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Male
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Mutation / genetics*
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Polymerase Chain Reaction
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Polymorphism, Single-Stranded Conformational
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Wilms Tumor / genetics*
Substances
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DNA Primers
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Glypicans
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Heparan Sulfate Proteoglycans