Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

X Bu; L Bernstein; R K Brynes

doi:10.1038/sj.bjc.6600362

Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

Br J Cancer. 2002 Jul 1;87(1):28-30. doi: 10.1038/sj.bjc.6600362.

Authors

X Bu¹, L Bernstein, R K Brynes

Affiliation

¹ Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.

Abstract

Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.

MeSH terms

Adolescent
Adult
Aged
Child
Child, Preschool
Female
Genetic Predisposition to Disease*
Humans
Incidence
Infant
Infant, Newborn
Male
Middle Aged
SEER Program*
Sarcoma, Synovial / epidemiology
Sarcoma, Synovial / etiology
Sarcoma, Synovial / genetics*
Soft Tissue Neoplasms / epidemiology
Soft Tissue Neoplasms / etiology
Soft Tissue Neoplasms / genetics*
Translocation, Genetic*
X Chromosome / genetics*