Abstract
The RUNX family of transcription factors plays pivotal roles during normal development and in neoplasias. Recent data involve RUNX3 as an important tumor suppressor in gastric cancers and pose interesting questions about how perturbed levels and interspecific competition among RUNX family members may contribute to tumorigenesis.
MeSH terms
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Animals
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Cell Transformation, Neoplastic / pathology*
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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Core Binding Factor alpha Subunits
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DNA-Binding Proteins / deficiency
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DNA-Binding Proteins / physiology*
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Disease Progression
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Disease Susceptibility
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Gene Expression Regulation, Neoplastic
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Genes, Tumor Suppressor
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Humans
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Loss of Heterozygosity
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Mice
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Mice, Knockout
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Neoplasm Proteins*
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Proto-Oncogene Proteins*
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Stomach Neoplasms / genetics
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Stomach Neoplasms / metabolism*
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Stomach Neoplasms / pathology
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Transcription Factors / deficiency
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Transcription Factors / physiology*
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Transforming Growth Factor beta / pharmacology
Substances
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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Core Binding Factor alpha Subunits
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DNA-Binding Proteins
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Neoplasm Proteins
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Proto-Oncogene Proteins
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RUNX1 protein, human
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Runx1 protein, mouse
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Runx3 protein, human
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Runx3 protein, mouse
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Transcription Factors
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Transforming Growth Factor beta