Abstract
The present study attempts to shed more light on the role of hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) in hepatoma cells. We initially examined, by reverse transcription-polymerase chain reaction (RT-PCR), the HIP/PAP transcripts present in human hepatoma cell lines of different origins and with different grades of differentiation and genetic profiles. We also used DNA sequencing analysis to investigate the structure of the HIP/PAP gene. Further investigation is necessary to define the role of HIP/PAP during the development of human hepatocellular carcinoma and to ascertain whether the use of different transcripts is helpful in regulating HIP/PAP expression in transformed liver cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute-Phase Proteins / biosynthesis*
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Acute-Phase Proteins / genetics
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Antigens, Neoplasm*
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Biomarkers, Tumor*
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Carcinoma, Hepatocellular / metabolism*
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Carcinoma, Hepatocellular / pathology
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Humans
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Lectins, C-Type*
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Liver Neoplasms / metabolism*
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N-Glycosyl Hydrolases*
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Pancreatitis / complications
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Pancreatitis-Associated Proteins
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Plant Proteins / biosynthesis*
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Plant Proteins / genetics
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RNA, Messenger / biosynthesis
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Ribosome Inactivating Proteins, Type 1
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Tumor Cells, Cultured
Substances
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Acute-Phase Proteins
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Antigens, Neoplasm
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Biomarkers, Tumor
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Lectins, C-Type
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Pancreatitis-Associated Proteins
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Plant Proteins
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REG3A protein, human
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RNA, Messenger
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Ribosome Inactivating Proteins, Type 1
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N-Glycosyl Hydrolases
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pokeweed antiviral protein