Abstract
We investigated PvuII and XbaI polymorphism in the estrogen receptor gene (ERG) and HLA-DRB1*1501 positivity in 116 conventional multiple sclerosis (MS) patients and 101 healthy controls in a Japanese population. Logistic analysis revealed independent associations of [P] allele in the profiles for PvuII (p=0.0005, adjusted odds ratio (aOR)=3.17) and DRB1*1501 (p=0.0089, aOR=2.61) with conventional MS. Synergistic elevated risk of MS due to interaction between the [P] allele and HLA-DRB1*1501 allele was found among female patients (odds ratio=16.0; 95% CI=3.99-63.8, p<0.0001). The [P] allele-positive patients with disease duration of more than 5 years had a significantly higher progression index (PI) of disability (p=0.0230) and a worse ranked MS severity score (p=0.0152) than their non-[P] counterparts.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
DNA Mutational Analysis
-
Deoxyribonucleases, Type II Site-Specific / genetics
-
Female
-
Gene Frequency / genetics
-
Genetic Predisposition to Disease / genetics*
-
Genetic Testing
-
HLA-DR Antigens / genetics*
-
HLA-DR Antigens / immunology
-
HLA-DRB1 Chains
-
Humans
-
Japan
-
Logistic Models
-
Male
-
Middle Aged
-
Multiple Sclerosis / genetics*
-
Multiple Sclerosis / immunology
-
Multiple Sclerosis / physiopathology
-
Polymorphism, Genetic / genetics*
-
Polymorphism, Genetic / immunology
-
Prognosis
-
Receptors, Estrogen / genetics*
-
Receptors, Estrogen / immunology
-
Sex Factors
Substances
-
HLA-DR Antigens
-
HLA-DRB1 Chains
-
Receptors, Estrogen
-
endodeoxyribonuclease XBAI
-
CAGCTG-specific type II deoxyribonucleases
-
Deoxyribonucleases, Type II Site-Specific