Abstract
The Adenomatous Polyposis Coli (APC) Gene is a tumor suppressor gene located in the chromosome 5q21. It has a sequence of 2843 amino acids and a weight of 312 kD. The mutation of the APC gene occurs at the early stages of most sporadic colorectal cancers; and up to 30% in familial adenomatous polyposis. The absence of APC will indicate the inadequate migration of colon mucous cells and its accumulation resulting in polyps formation, which determines a stage in carcinogenicity. An adequate study in prone groups may lead to chemoprophylaxis and/or early treatment of polyps.
MeSH terms
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Adenomatous Polyposis Coli / ethnology
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Adenomatous Polyposis Coli / genetics
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Adenomatous Polyposis Coli / pathology
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Adenomatous Polyposis Coli Protein / chemistry
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Adenomatous Polyposis Coli Protein / physiology*
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Amino Acid Substitution
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Anticarcinogenic Agents / therapeutic use
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Aspirin / therapeutic use
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Cadherins / physiology
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Cell Adhesion / genetics
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Cell Division / genetics
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Cell Movement / genetics
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Cell Transformation, Neoplastic / genetics
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Chromosomes, Human, Pair 5 / genetics
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / prevention & control
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Cytoskeletal Proteins / physiology
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Europe, Eastern / ethnology
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Female
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Genes, APC*
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Humans
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Jews / genetics
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Male
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Mutation, Missense
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Neoplastic Syndromes, Hereditary / epidemiology
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Neoplastic Syndromes, Hereditary / genetics
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Point Mutation
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Sequence Deletion
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Trans-Activators / physiology
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beta Catenin
Substances
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Adenomatous Polyposis Coli Protein
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Anti-Inflammatory Agents, Non-Steroidal
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Anticarcinogenic Agents
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CTNNB1 protein, human
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Cadherins
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Cytoskeletal Proteins
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Trans-Activators
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beta Catenin
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Aspirin