Maspin is a tumour suppressor that inhibits breast cancer tumour metastasis in vivo

Breast Cancer Res. 2002;4(4):137-40. doi: 10.1186/bcr437. Epub 2002 May 16.

Abstract

Maspin is a member of the serpin family of serine proteases and functions as a tumour suppressor. A study using a new syngeneic mouse model for breast cancer suggests that maspin can inhibit metastasis in vivo.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology
  • Epithelial Cells / enzymology
  • Female
  • Genes, Tumor Suppressor
  • Humans
  • Mammary Neoplasms, Experimental / enzymology
  • Mammary Neoplasms, Experimental / genetics
  • Mammary Neoplasms, Experimental / pathology
  • Mice
  • Mice, Inbred BALB C
  • Muscle, Smooth / cytology
  • Muscle, Smooth / enzymology
  • Neoplasm Metastasis
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / physiology*
  • Neoplasm Transplantation
  • Proteins / genetics
  • Proteins / physiology*
  • Rats
  • Recombinant Fusion Proteins / physiology
  • Serpins / genetics
  • Serpins / physiology*
  • Transfection
  • Transplantation, Isogeneic

Substances

  • Neoplasm Proteins
  • Proteins
  • Recombinant Fusion Proteins
  • SERPIN-B5
  • Serpins