Abstract
Maspin is a member of the serpin family of serine proteases and functions as a tumour suppressor. A study using a new syngeneic mouse model for breast cancer suggests that maspin can inhibit metastasis in vivo.
MeSH terms
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Animals
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Breast Neoplasms / enzymology
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Breast Neoplasms / genetics
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Breast Neoplasms / pathology
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology
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Epithelial Cells / enzymology
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Female
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Genes, Tumor Suppressor
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Humans
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Mammary Neoplasms, Experimental / enzymology
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Mammary Neoplasms, Experimental / genetics
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Mammary Neoplasms, Experimental / pathology
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Mice
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Mice, Inbred BALB C
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Muscle, Smooth / cytology
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Muscle, Smooth / enzymology
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Neoplasm Metastasis
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology*
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Neoplasm Transplantation
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Proteins / genetics
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Proteins / physiology*
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Rats
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Recombinant Fusion Proteins / physiology
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Serpins / genetics
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Serpins / physiology*
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Transfection
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Transplantation, Isogeneic
Substances
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Neoplasm Proteins
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Proteins
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Recombinant Fusion Proteins
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SERPIN-B5
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Serpins