Abstract
Interleukin 10 (IL-10) is an immunosuppressive cytokine produced by T-lymphocytes, and is a regulatory molecule for angiogenesis in various cancers. We examined IL-10 and vascular endothelial growth factor (VEGF) gene expression in 45 esophageal cancer patients who underwent surgical resection. Thirty-seven (82.2%) of the 45 esophageal cancers revealed IL-10 gene expression. VEGF121, VEGF165 and VEGF189 isoforms were detected in 93.3% (42/45), 55.6% (25/45) and 26.7% (12/45) of cases, respectively. IL-10 gene expression was significantly correlated with VEGF121 gene expression (P=0.0039, Fisher's test). The results suggested that IL-10 stimulates angiogenic factor gene expression.
MeSH terms
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Alternative Splicing
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Angiogenesis Inducing Agents / biosynthesis*
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Angiogenesis Inducing Agents / genetics
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Angiogenesis Inducing Agents / physiology
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / metabolism*
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Esophageal Neoplasms / genetics
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Esophageal Neoplasms / metabolism*
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Female
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Gene Expression Regulation, Neoplastic*
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Humans
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Interleukin-10 / biosynthesis*
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Interleukin-10 / genetics
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Interleukin-10 / physiology
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Male
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology
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Neovascularization, Pathologic / genetics
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Neovascularization, Pathologic / metabolism
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Protein Isoforms / biosynthesis
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Protein Isoforms / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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RNA, Neoplasm / biosynthesis
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RNA, Neoplasm / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Vascular Endothelial Growth Factor A*
Substances
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Angiogenesis Inducing Agents
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Neoplasm Proteins
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Protein Isoforms
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RNA, Messenger
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RNA, Neoplasm
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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Interleukin-10