Abstract
The reelin signaling pathway plays a crucial role during the development of laminated structures in the mammalian brain. Reelin, which is synthesized and secreted by Cajal-Retzius cells in the marginal zone of the neocortex and hippocampus, is proposed to act as a stop signal for migrating neurons. Here we show that a decreased expression of reelin mRNA by hippocampal Cajal-Retzius cells correlates with the extent of migration defects in the dentate gyrus of patients with temporal lobe epilepsy. These results suggest that reelin is required for normal neuronal lamination in humans, and that deficient reelin expression may be involved in migration defects associated with temporal lobe epilepsy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Adolescent
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Adult
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Cell Adhesion Molecules, Neuronal / genetics
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Cell Adhesion Molecules, Neuronal / metabolism*
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Cell Count
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Cell Movement
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Child, Preschool
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Dentate Gyrus / pathology
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Epilepsy, Temporal Lobe / metabolism*
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Epilepsy, Temporal Lobe / pathology
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Extracellular Matrix Proteins / genetics
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Extracellular Matrix Proteins / metabolism*
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Female
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Hippocampus / metabolism
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Hippocampus / pathology
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Humans
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In Situ Hybridization
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LDL-Receptor Related Proteins
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Male
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Middle Aged
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Nerve Tissue Proteins / biosynthesis
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Neurons / metabolism*
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Neurons / pathology
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Polymerase Chain Reaction
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RNA, Messenger / metabolism
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Receptors, LDL / biosynthesis
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Receptors, Lipoprotein / biosynthesis
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Reelin Protein
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Serine Endopeptidases
Substances
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Adaptor Proteins, Signal Transducing
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Cell Adhesion Molecules, Neuronal
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DAB1 protein, human
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Extracellular Matrix Proteins
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LDL-Receptor Related Proteins
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Nerve Tissue Proteins
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RNA, Messenger
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Receptors, LDL
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Receptors, Lipoprotein
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Reelin Protein
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VLDL receptor
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low density lipoprotein receptor-related protein 8
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RELN protein, human
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Serine Endopeptidases