[VNTR polymorphisms of the serotonin transporter and dopamine transporter genes in male opiate addicts]

A R Galeeva; A E Gareeva; E B Iur'ev; E K Khusnutdinova

[VNTR polymorphisms of the serotonin transporter and dopamine transporter genes in male opiate addicts]

Mol Biol (Mosk). 2002 Jul-Aug;36(4):593-8.

[Article in Russian]

Authors

A R Galeeva¹, A E Gareeva, E B Iur'ev, E K Khusnutdinova

Affiliation

¹ Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054 Russia.

PMID: 12173460

Abstract

VNTR polymorphisms of the serotonin transporter (hSERT) and dopamine transporter (DAT1) gene were studied in male opiate addicts. Samples of ethnic Russians and ethnic Tatars did not differ in genotype and allele frequencies. Homozygosity at hSERT (especially 10/10) was associated with early opiate addiction, while genotype 12/10 proved to be protective. In the case of DAT1, genotype 9/9 was associated with early opiate addiction. The combination of hSERT genotype 10/10 with DAT1 genotype 10/10 was shown to be a risk factor of opiate abuse under 16 years of age.

Publication types

English Abstract

MeSH terms

Adolescent
Adult
Carrier Proteins / genetics*
Case-Control Studies
Dopamine Plasma Membrane Transport Proteins
Heterozygote
Humans
Male
Membrane Glycoproteins / genetics*
Membrane Transport Proteins / genetics*
Nerve Tissue Proteins*
Opioid-Related Disorders / ethnology
Opioid-Related Disorders / genetics*
Polymorphism, Genetic*
Serotonin Plasma Membrane Transport Proteins

Substances

Carrier Proteins
Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
SLC6A3 protein, human
SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins