Abstract
Trichothiodystrophy (TTD) is a complex disorder caused by mutations in the XPD gene which affect both DNA repair and transcription. A mouse with a TTD mutation has now been found to display remarkable signs of premature ageing.
MeSH terms
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Abnormalities, Multiple*
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Aging / physiology*
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Aging, Premature / genetics
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Aging, Premature / physiopathology*
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Animals
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Cockayne Syndrome / genetics
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DNA Damage
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DNA Helicases*
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DNA Repair*
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DNA-Binding Proteins / metabolism
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Disease Models, Animal
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Hair / abnormalities
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Humans
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Mice
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Mutation
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Phenotype
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Proteins / genetics
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Transcription Factors*
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Transcription, Genetic*
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Xeroderma Pigmentosum Group A Protein
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Xeroderma Pigmentosum Group D Protein
Substances
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DNA-Binding Proteins
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Proteins
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Transcription Factors
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XPA protein, human
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Xeroderma Pigmentosum Group A Protein
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Xpa protein, mouse
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DNA Helicases
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Xeroderma Pigmentosum Group D Protein
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ERCC2 protein, human
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Ercc2 protein, mouse