Association between dopamine transporter gene polymorphism and susceptibility to Parkinson's disease in Japan

Masataka Nishimura; Ryuji Kaji; Mitsuhiro Ohta; Ikuko Mizuta; Sadako Kuno

doi:10.1002/mds.10187

Association between dopamine transporter gene polymorphism and susceptibility to Parkinson's disease in Japan

Mov Disord. 2002 Jul;17(4):831-2. doi: 10.1002/mds.10187.

Authors

Masataka Nishimura¹, Ryuji Kaji, Mitsuhiro Ohta, Ikuko Mizuta, Sadako Kuno

Affiliation

¹ Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan. m_nishim@clin.med.tokushima-u.ac.jp

PMID: 12210886
DOI: 10.1002/mds.10187

Abstract

We studied a polymorphism in the dopamine transporter (DAT) gene in 236 Japanese patients with Parkinson's disease (PD) and compared the results with 220 controls. The 1215A/G genotype of the DAT gene was significantly different between PD patients and controls, suggesting a possible involvement of DAT in genetic susceptibility to PD.

MeSH terms

Adult
Aged
Aged, 80 and over
Dopamine Plasma Membrane Transport Proteins
Female
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics
Genetics, Population
Genotype
Humans
Japan
Male
Membrane Glycoproteins*
Membrane Transport Proteins / genetics*
Middle Aged
Nerve Tissue Proteins*
Parkinson Disease / genetics*
Polymorphism, Genetic / genetics*

Substances

Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
Membrane Transport Proteins
Nerve Tissue Proteins
SLC6A3 protein, human