Abstract
Fas antigen (Fas) is a cell surface receptor molecule introducing apoptosis-inducing signals into Fas-bearing cells by stimulation with Fas ligand or agonistic anti-Fas monoclonal antibodies. Fas system has been implicated in the regulation of homeostasis of peripheral T and B lymphocytes including elimination of autoreactive cells, and in the exclusion of tumor and virus-infected cells. Fas system, however, also plays a role in the mechanisms responsible for tissue disruption in tissue-specific autoimmune disease and fulminant hepatitis. In this review, I describe how we prepared the original anti-human Fas monoclonal antibody with associated cell-killing activity, and I propose here a strategy of therapeutic use of a novel anti-Fas monoclonal antibody for autoimmune and other diseases.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal / toxicity
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Apoptosis / drug effects
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Apoptosis / physiology*
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Autoimmune Diseases / therapy
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Cricetinae
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Cross Reactions
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Disease Models, Animal
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Fas Ligand Protein
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Forecasting
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Hepatitis / etiology
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Humans
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Immunologic Surveillance / physiology
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Lymphoproliferative Disorders / genetics
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Lymphoproliferative Disorders / immunology
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Membrane Glycoproteins / physiology
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Mice
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Mice, Inbred MRL lpr
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Mice, Inbred Strains
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Organ Specificity
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Species Specificity
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T-Lymphocyte Subsets / immunology
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fas Receptor / immunology
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fas Receptor / physiology*
Substances
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Antibodies, Monoclonal
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FASLG protein, human
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Fas Ligand Protein
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Fasl protein, mouse
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Membrane Glycoproteins
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fas Receptor