Abstract
We demonstrate that human herpesvirus 8, obtained from the lymphoma cell line BC-3 as well as from Kaposi's sarcoma lesions, carries a gene that encodes a functional thymidylate synthase (TS). The particular characteristics of this enzyme are studied and compared to the characteristics of TSs encoded by other organisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Deoxyuracil Nucleotides / pharmacology
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Enzyme Inhibitors / pharmacology
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Fluorodeoxyuridylate / pharmacology
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Genes, Viral
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Herpesvirus 3, Human / enzymology
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Herpesvirus 3, Human / genetics
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Herpesvirus 8, Human / enzymology*
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Herpesvirus 8, Human / genetics
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Humans
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Lymphoma
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Molecular Sequence Data
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Sarcoma, Kaposi / pathology
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Sarcoma, Kaposi / virology*
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Thymidylate Synthase / antagonists & inhibitors
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Thymidylate Synthase / genetics
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Thymidylate Synthase / metabolism*
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Tumor Cells, Cultured
Substances
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Deoxyuracil Nucleotides
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Enzyme Inhibitors
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Fluorodeoxyuridylate
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iododeoxyuridylate
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Thymidylate Synthase