Allelic frequency of the MCP-1 promoter -2518 polymorphism in the Korean population and in Korean patients with rheumatoid arthritis, systemic lupus erythematosus and adult-onset Still's disease

S-Y Hwang; M-L Cho; B Park; J-Y Kim; Y-H Kim; D-J Min; J-K Min; H-Y Kim

doi:10.1046/j.1365-2370.2002.00346.x

Allelic frequency of the MCP-1 promoter -2518 polymorphism in the Korean population and in Korean patients with rheumatoid arthritis, systemic lupus erythematosus and adult-onset Still's disease

Eur J Immunogenet. 2002 Oct;29(5):413-6. doi: 10.1046/j.1365-2370.2002.00346.x.

Authors

S-Y Hwang¹, M-L Cho, B Park, J-Y Kim, Y-H Kim, D-J Min, J-K Min, H-Y Kim

Affiliation

¹ Institute of Immunobiology, Catholic Institutes of Medical Science, The Catholic University of Korea, Seoul, Korea. dutuya@cmc.cuk.ac.kr

PMID: 12358851
DOI: 10.1046/j.1365-2370.2002.00346.x

Abstract

The frequency of the monocyte chemoattractant protein-1 (MCP-1) -2518 G-type polymorphism in Koreans is significantly higher than the frequencies reported for Caucasians and Afro-Americans. The G- vs. A-allele profile in patients with systemic autoimmune diseases is similar to that in healthy Koreans, and does not appear to contribute to elevated MCP-1 production in patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arthritis, Rheumatoid / genetics*
Chemokine CCL2 / blood
Chemokine CCL2 / genetics*
Chemokine CCL2 / metabolism
Gene Frequency
Humans
Korea
Leukocytes, Mononuclear / metabolism
Lupus Erythematosus, Systemic / genetics*
Polymorphism, Genetic
Promoter Regions, Genetic*
Still's Disease, Adult-Onset / genetics*

Substances

Chemokine CCL2