Objective: To elucidate the correlation between angiotensin II type 1 receptor (AT1R) gene polymorphism and type 2 diabetes mellitus (T2DM) complicated by hypertension.
Methods: AT1R gene polymorphism was determined by PCR in 132 T2DM patients complicated by hypertension and 107 normotensive T2DM patients.
Results: The frequencies of AA and AC genotypes in the 2 groups were 88.79% vs 96.97% and 11.21% vs 3.03% respectively, and those for A and C allele were 94.39% vs 98.48% and 5.61% vs 1.51%, showing significant difference between the 2 groups (P<0.05). It was suggested that AT1R gene polymorphism was associated with T2DM complicated by hypertension, and the patients had significantly prolonged courses of DM when complicated by hypertension. Normotensive DM patients did not differ from DM patients with only elevated diastolic blood pressure in terms of AT1R-A1166-C gene polymorphism, but showed significant difference from DM patients with elevated systolic blood pressure.
Conclusion: AT1R gene contributed to T2DM complicated by hypertension, but is only associated with cases of elevated systolic blood pressure.