Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system

Javier S Burgos; Carlos Ramirez; Isabel Sastre; María J Bullido; Fernando Valdivieso

doi:10.1128/jvi.76.23.12394-12398.2002

Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system

J Virol. 2002 Dec;76(23):12394-8. doi: 10.1128/jvi.76.23.12394-12398.2002.

Authors

Javier S Burgos¹, Carlos Ramirez, Isabel Sastre, María J Bullido, Fernando Valdivieso

Affiliation

¹ Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Abstract

Apolipoprotein E (ApoE), a constituent of the lipoproteins, may be relevant in herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS), since HSV-1 binds to human serum ApoE lipoproteins. This study demonstrates the involvement of ApoE in the hematogenous route of HSV-1 to the CNS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apolipoproteins E / blood*
Apolipoproteins E / deficiency
Apolipoproteins E / genetics
Central Nervous System / virology
Central Nervous System Infections / blood*
Central Nervous System Infections / virology*
DNA, Viral / blood
DNA, Viral / genetics
Female
Herpes Simplex / blood*
Herpes Simplex / virology*
Herpesvirus 1, Human / genetics
Herpesvirus 1, Human / pathogenicity*
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout
Organ Specificity
Protein Binding
Time Factors
Viremia / blood
Viremia / virology

Substances

Apolipoproteins E
DNA, Viral