Abstract
We have characterized a 185-kb contig surrounding a transgene on distal mouse chromosome 11, the insertion of which has caused a recessive phenotype with skeletal malformations. By cDNA selection and sequencing we have found six genes (Lasp1, Rpl23, Mllt6, Pip5k2b, Psmb3, Zfp144), one truncated gene (Mel13), and one pseudogene (Rps15-ps) within this region. The murine Mllt6 gene is new, it was identified by its high homology (90% identity) with the human homologue MLLT6. Psmb3 and Pip5k2b had not yet been assigned to mouse chromosomes. A comparison with the corresponding region on human chromosome 17q12 revealed several small-scale rearrangements during evolutionary divergence within this cluster of densely packed genes.
Copyright 2002 S. Karger AG, Basel
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Base Sequence
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Chromosomes, Mammalian / genetics*
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Collagen / genetics
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Collagen Type I*
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Collagen Type I, alpha 1 Chain
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Cytoskeletal Proteins
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DNA Transposable Elements
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DNA, Complementary / genetics
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DNA-Binding Proteins / genetics
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Evolution, Molecular
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Gene Rearrangement
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Genetic Linkage
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Homeodomain Proteins / genetics
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Humans
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Iron-Sulfur Proteins
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LIM Domain Proteins
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Lac Operon
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Mice
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Mice, Transgenic
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Mitochondrial Proteins
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Molecular Sequence Data
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Multigene Family
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Mutagenesis, Insertional
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Mutation*
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Neoplasm Proteins / genetics
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Physical Chromosome Mapping
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Proteins / genetics
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Pseudogenes
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Ribosomal Proteins / genetics
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Species Specificity
Substances
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Adaptor Proteins, Signal Transducing
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Cisd3 protein, mouse
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Collagen Type I
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Collagen Type I, alpha 1 Chain
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Cytoskeletal Proteins
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DNA Transposable Elements
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DNA, Complementary
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DNA-Binding Proteins
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Homeodomain Proteins
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Iron-Sulfur Proteins
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LASP1 protein, human
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LIM Domain Proteins
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Lasp1 protein, mouse
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MLLT6 protein, human
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Mitochondrial Proteins
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Mllt6 protein, mouse
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Neoplasm Proteins
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Proteins
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Ribosomal Proteins
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ribosomal protein S15
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Collagen
Associated data
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GENBANK/AY050217
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GENBANK/AY050218