Abstract
Venous thrombosis of transverse and sigmoid sinuses was diagnosed in a 3-year-old child who is a carrier of the G20210A prothrombin gene mutation. Recombinant tissue plasminogen activator (rt-PA) treatment was started 9 days following the onset of neurologic signs. Nine days of rt-PA therapy completely dissolved the thrombus. This case provides further evidence that rt-PA is useful and safe in children with thrombosis.
MeSH terms
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Brain / pathology
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Cerebral Veins*
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Child, Preschool
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Genetic Carrier Screening
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Humans
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Magnetic Resonance Imaging
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Male
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Plasminogen Activators / therapeutic use
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Prothrombin / genetics*
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Recombinant Proteins / therapeutic use
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Tissue Plasminogen Activator / therapeutic use*
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Venous Thrombosis / drug therapy*
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Venous Thrombosis / genetics
Substances
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Recombinant Proteins
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Prothrombin
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Plasminogen Activators
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Tissue Plasminogen Activator