Recombinant plasminogen activator therapy for cerebral vein thrombosis in a child carrier of prothrombin gene mutation

J Pediatr Hematol Oncol. 2002 Dec;24(9):769-71. doi: 10.1097/00043426-200212000-00019.

Abstract

Venous thrombosis of transverse and sigmoid sinuses was diagnosed in a 3-year-old child who is a carrier of the G20210A prothrombin gene mutation. Recombinant tissue plasminogen activator (rt-PA) treatment was started 9 days following the onset of neurologic signs. Nine days of rt-PA therapy completely dissolved the thrombus. This case provides further evidence that rt-PA is useful and safe in children with thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Brain / pathology
  • Cerebral Veins*
  • Child, Preschool
  • Genetic Carrier Screening
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Plasminogen Activators / therapeutic use
  • Prothrombin / genetics*
  • Recombinant Proteins / therapeutic use
  • Tissue Plasminogen Activator / therapeutic use*
  • Venous Thrombosis / drug therapy*
  • Venous Thrombosis / genetics

Substances

  • Recombinant Proteins
  • Prothrombin
  • Plasminogen Activators
  • Tissue Plasminogen Activator