[Association study of heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase gene]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Dec;19(6):499-501.
[Article in Chinese]

Abstract

Objective: To detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene.

Methods: Genotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls.

Results: Weak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (chi(2)=7.41, P=0.025), and genotype AA was higher in the former. The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (chi(2)=5.69, P=0.017).

Conclusion: The results suggested that liability to heroin-dependence was associated with -287 A/G polymorphism of COMT gene.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Catechol O-Methyltransferase / genetics*
  • DNA / genetics
  • DNA / metabolism
  • DNA Restriction Enzymes / metabolism
  • Female
  • Gene Frequency
  • Genotype
  • Heroin Dependence / enzymology
  • Heroin Dependence / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics

Substances

  • DNA
  • Catechol O-Methyltransferase
  • DNA Restriction Enzymes