Abstract
In a 66 years old female patient with acute myeloblastic leukemia (AML) complex chromosomal rearrangements involving 11q23 were diagnosed by G-banding and confirmed by different fluorescence in situ hybridization (FISH) techniques. The amplification of MLL gene differed in various sidelines as shown by locus specific probes for 11q23 and 11q13. Complex karyotype rearrangements involving deletions del(5)(q31) and del(7)(q31) were verified by multicolor fluorescence in situ hybridization (mFISH).
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Chromosome Deletion
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Chromosomes, Human, Pair 11
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Chromosomes, Human, Pair 5
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Chromosomes, Human, Pair 7
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DNA-Binding Proteins / genetics*
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Female
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Gene Amplification / physiology*
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Gene Rearrangement
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Genetic Variation
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Histone-Lysine N-Methyltransferase
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Humans
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In Situ Hybridization, Fluorescence
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Karyotyping
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Leukemia, Myeloid, Acute / genetics*
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Myeloid-Lymphoid Leukemia Protein
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Proto-Oncogenes*
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Transcription Factors*
Substances
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DNA-Binding Proteins
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KMT2A protein, human
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Transcription Factors
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Myeloid-Lymphoid Leukemia Protein
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Histone-Lysine N-Methyltransferase