RNA interference: the fragile X syndrome connection

Curr Biol. 2002 Dec 23;12(24):R852-4. doi: 10.1016/s0960-9822(02)01352-0.

Abstract

Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila Proteins*
  • Endoribonucleases / genetics
  • Endoribonucleases / metabolism
  • Fragile X Mental Retardation Protein
  • Fragile X Syndrome / genetics*
  • Humans
  • Mice
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • RNA Interference*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Ribonuclease III
  • Ribonucleoproteins / metabolism

Substances

  • Drosophila Proteins
  • FMR1 protein, Drosophila
  • FMR1 protein, human
  • Fmr1 protein, mouse
  • Nerve Tissue Proteins
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • Fragile X Mental Retardation Protein
  • Endoribonucleases
  • Ribonuclease III