Abstract
Fragile X syndrome is caused by loss of expression of FMRP, a protein proposed to act as a regulator of mRNA translation which promotes synaptic maturation and function. Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi.
MeSH terms
-
Animals
-
Drosophila Proteins*
-
Endoribonucleases / genetics
-
Endoribonucleases / metabolism
-
Fragile X Mental Retardation Protein
-
Fragile X Syndrome / genetics*
-
Humans
-
Mice
-
Nerve Tissue Proteins / genetics
-
Nerve Tissue Proteins / metabolism*
-
RNA Interference*
-
RNA-Binding Proteins / genetics
-
RNA-Binding Proteins / metabolism*
-
Ribonuclease III
-
Ribonucleoproteins / metabolism
Substances
-
Drosophila Proteins
-
FMR1 protein, Drosophila
-
FMR1 protein, human
-
Fmr1 protein, mouse
-
Nerve Tissue Proteins
-
RNA-Binding Proteins
-
Ribonucleoproteins
-
Fragile X Mental Retardation Protein
-
Endoribonucleases
-
Ribonuclease III