Abstract
The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA.
MeSH terms
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BRCA2 Protein / genetics
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Breast Neoplasms / genetics*
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Breast Neoplasms / prevention & control
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DNA-Binding Proteins / genetics*
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Female
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Gene Expression Regulation
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Genes, BRCA2*
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Humans
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Models, Genetic
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Ovarian Neoplasms / genetics*
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Ovarian Neoplasms / prevention & control
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Rad51 Recombinase
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Recombination, Genetic*
Substances
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BRCA2 Protein
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DNA-Binding Proteins
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RAD51 protein, human
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Rad51 Recombinase