BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?

Mol Cell. 2002 Dec;10(6):1262-3. doi: 10.1016/s1097-2765(02)00789-x.

Abstract

The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA.

Publication types

  • Comment

MeSH terms

  • BRCA2 Protein / genetics
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / prevention & control
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Expression Regulation
  • Genes, BRCA2*
  • Humans
  • Models, Genetic
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / prevention & control
  • Rad51 Recombinase
  • Recombination, Genetic*

Substances

  • BRCA2 Protein
  • DNA-Binding Proteins
  • RAD51 protein, human
  • Rad51 Recombinase