FC gamma RIIa polymorphism in patients with rheumatoid arthritis

Clin Exp Rheumatol. 2002 Nov-Dec;20(6):841-4.

Abstract

Objective: Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2.

Methods: Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction technique with allele specific primers.

Results: No significant relation between Fc gamma RIIa genotypes and susceptibility to RA was observed, but extraarticular complications with high frequency were revealed in patients with R/R131 genotype.

Conclusion: The results suggest that the Fc gamma RIIa polymorphism is not a risk factor for RA.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antigens, CD / genetics*
  • Arthritis, Rheumatoid / epidemiology
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / physiopathology
  • DNA / analysis
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Poland / epidemiology
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Receptors, IgG / genetics*

Substances

  • Antigens, CD
  • Fc gamma receptor IIA
  • Receptors, IgG
  • DNA