Abstract
We report a case of therapy-related myelodysplastic syndrome (t-MDS) with t(10;16)(q22;p13), in which novel fusion transcripts of the MORF and CBP genes were detected. In one MORF-CBP fusion transcript, exon 15 of the MORF gene was fused in frame with exon 5 of the CBP gene. In a reciprocal CBP-MORF transcript, exon 4 of the CBP gene was fused in frame with exon 16 of the MORF gene. This is the first reported case of t-MDS associated with t(10;16), and provides molecular evidence that the novel MORF-CBP and/or CBP-MORF fusion protein(s) might play an important role in the development of t-MDS.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetyltransferases / genetics*
-
Antineoplastic Combined Chemotherapy Protocols / adverse effects
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Carrier Proteins / genetics*
-
Chromosomes, Human, Pair 10
-
Chromosomes, Human, Pair 16
-
Cytarabine / administration & dosage
-
Female
-
Gene Rearrangement
-
Histone Acetyltransferases
-
Humans
-
Idarubicin / administration & dosage
-
Leukemia, Myeloid, Acute / drug therapy
-
Middle Aged
-
Myelodysplastic Syndromes / chemically induced
-
Myelodysplastic Syndromes / genetics*
-
Reverse Transcriptase Polymerase Chain Reaction
-
Saccharomyces cerevisiae Proteins / genetics*
-
Sequence Analysis, DNA
-
Translocation, Genetic*
Substances
-
Carrier Proteins
-
Saccharomyces cerevisiae Proteins
-
citrate-binding transport protein
-
Cytarabine
-
Acetyltransferases
-
Histone Acetyltransferases
-
Idarubicin