Abstract
We report a case of de novo acute lymphoblastic leukemia with tandem amplification of the AML1 gene located in a chromosome marker that originated from chromosome 21 and a long event-free survival.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
-
Asparaginase / administration & dosage
-
Child
-
Chromosome Aberrations*
-
Chromosome Painting
-
Chromosomes, Human, Pair 21 / genetics*
-
Chromosomes, Human, Pair 21 / ultrastructure
-
Core Binding Factor Alpha 2 Subunit
-
Cyclophosphamide / administration & dosage
-
DNA-Binding Proteins / genetics*
-
Daunorubicin / administration & dosage
-
Female
-
Gene Amplification*
-
Humans
-
Neoplasm Proteins / genetics*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
-
Prednisolone / administration & dosage
-
Proto-Oncogene Proteins*
-
Remission Induction
-
Transcription Factors / genetics*
-
Vincristine / administration & dosage
Substances
-
Core Binding Factor Alpha 2 Subunit
-
DNA-Binding Proteins
-
Neoplasm Proteins
-
Proto-Oncogene Proteins
-
RUNX1 protein, human
-
Transcription Factors
-
Vincristine
-
Cyclophosphamide
-
Prednisolone
-
Asparaginase
-
Daunorubicin