Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder

Neurosci Lett. 2003 Feb 27;338(2):115-8. doi: 10.1016/s0304-3940(02)01338-1.

Abstract

We previously observed in four autistic patients a new allele (GXAlu 5) of the GXAlu microsatellite marker located in intron 27b of the neurofibromatosis type 1 (NF1) gene (17q11.2). This large intron contains the OMGP gene, coding for the oligodendrocyte myelin glycoprotein expressed by neurons and oligodendrocytes. In the present work, we analysed the distribution of a coding single nucleotide polymorphism (OMGP62) of the OMGP gene, the nearest gene to the GXAlu marker, in a control population (n=101) and in an autistic group (n=65). We observed no significant difference in allele distribution comparing these two groups (chi(2)=1.81; P=0.179). When distinguishing an autistic group with a developmental quotient (DQ) higher than 30 (n=37) and one with a DQ lower than 30 (n=28), we observed an association between allele A and the group with the highest DQ (P=0.015). We found no other polymorphism using SSCP screening and DNA sequencing in the OMGP coding region in 16 autistic patients bearing OMGP62 allele A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Autistic Disorder / genetics*
  • Child
  • Child, Preschool
  • GPI-Linked Proteins
  • Gene Frequency
  • Humans
  • Middle Aged
  • Myelin Proteins
  • Myelin-Associated Glycoprotein / genetics*
  • Myelin-Oligodendrocyte Glycoprotein
  • Polymorphism, Genetic

Substances

  • GPI-Linked Proteins
  • MOG protein, human
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Myelin-Oligodendrocyte Glycoprotein
  • OMG protein, human