Abstract
Multiple sclerosis (MS) is a chronic disease involving an inflammatory reaction within the white matter of the CNS, mediated by T cells, B cells and macrophages. The pathogenesis of MS may involve impaired activation-induced cell death of activated myelin-specific mature T cells. We investigated the mRNA expression of the apoptosis mediators cellular FLICE-inhibitory protein (cFLIP), caspase-8, CD95 and CD95L in peripheral blood mononuclear cells (PB MNCs) from MS patients using real-time PCR. The overall increased expression of the four key players in the CD95 pathway in relapsing-remitting MS suggests their involvement in the inflammatory process in this disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Age Factors
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Aged
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CASP8 and FADD-Like Apoptosis Regulating Protein
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Carrier Proteins / cerebrospinal fluid
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Carrier Proteins / genetics*
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Caspase 8
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Caspase 9
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Caspases / genetics
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Cell Line
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Fas Ligand Protein
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Female
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Gene Expression Regulation*
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Humans
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Intracellular Signaling Peptides and Proteins*
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Leukocytes, Mononuclear / metabolism*
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Male
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Membrane Glycoproteins / cerebrospinal fluid
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Membrane Glycoproteins / genetics*
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Middle Aged
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Multiple Sclerosis, Relapsing-Remitting / immunology*
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Polymerase Chain Reaction
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RNA, Messenger / analysis
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Time Factors
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Up-Regulation
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fas Receptor / cerebrospinal fluid
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fas Receptor / genetics*
Substances
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CASP8 and FADD-Like Apoptosis Regulating Protein
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CFLAR protein, human
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Carrier Proteins
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FASLG protein, human
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Fas Ligand Protein
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Intracellular Signaling Peptides and Proteins
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Membrane Glycoproteins
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RNA, Messenger
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fas Receptor
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CASP8 protein, human
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CASP9 protein, human
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Caspase 8
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Caspase 9
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Caspases