ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation

Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):972-80. doi: 10.1161/01.ATV.0000054661.21499.FB. Epub 2003 Jan 9.

Abstract

Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters / chemistry
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / physiology*
  • Animals
  • Apolipoproteins B / metabolism
  • Arteriosclerosis / blood
  • Arteriosclerosis / genetics
  • Cholesterol, HDL / metabolism
  • Disease Models, Animal
  • Female
  • Foam Cells / pathology
  • Humans
  • Infertility / genetics
  • Liver / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Knockout
  • Phenotype
  • Structure-Activity Relationship
  • Tangier Disease / genetics
  • Tangier Disease / metabolism

Substances

  • ABCA1 protein, human
  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters
  • Apolipoproteins B
  • Cholesterol, HDL