Abstract
Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.
MeSH terms
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ATP Binding Cassette Transporter 1
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ATP-Binding Cassette Transporters / chemistry
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ATP-Binding Cassette Transporters / genetics
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ATP-Binding Cassette Transporters / physiology*
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Animals
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Apolipoproteins B / metabolism
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Arteriosclerosis / blood
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Arteriosclerosis / genetics
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Cholesterol, HDL / metabolism
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Disease Models, Animal
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Female
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Foam Cells / pathology
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Humans
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Infertility / genetics
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Liver / metabolism
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Mice, Knockout
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Phenotype
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Structure-Activity Relationship
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Tangier Disease / genetics
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Tangier Disease / metabolism
Substances
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ABCA1 protein, human
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ATP Binding Cassette Transporter 1
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ATP-Binding Cassette Transporters
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Apolipoproteins B
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Cholesterol, HDL