Influence of cytokine and mannose binding protein gene polymorphisms on human T-cell leukemia virus type I (hTLV-I) provirus load in HTLV-I asymptomatic carriers

Hum Immunol. 2003 Apr;64(4):453-7. doi: 10.1016/s0198-8859(02)00829-7.

Abstract

Human T-cell leukemia virus type I (HTLV-I) provirus load differs more than 100-fold among carriers and a high provirus load in the peripheral blood mononuclear cells (PBMCs) is regarded as a risk factor for both preleukemic states and inflammatory diseases including HTLV-I-associated myelopathy (HAM). We examined polymorphisms in the genes for tumor necrosis factor (TNF), TNF receptor type 1 and 2, lymphotoxin (LT)-alpha, interleukin (IL)-1beta, IL-6, IL-10, monocyte chemoattractant protein (MCP)-1, and mannose binding protein (ManBP) in 143 HTLV-I carriers whether these polymorphisms affect the provirus load in the PBMCs of carriers. No significant association was observed between these polymorphisms and the provirus load. Homozygotes for a ManBP-variant allele, however, showed a tendency for the decreased number of provirus load. When combined, the data on the alleles of LT-alpha and MCP-1, HTLV-I carriers having high producer alleles of both genes showed a trend for increased provirus load. These data suggest that inflammation or an active immune response may induce an increased amount of HTLV-I-infected T cells, leading to a high provirus load.

MeSH terms

  • Alleles
  • Asian People
  • Carrier State
  • Cytokines / genetics*
  • Gene Rearrangement, T-Lymphocyte
  • HTLV-I Infections / diagnosis
  • Human T-lymphotropic virus 1 / isolation & purification*
  • Humans
  • Mannose-Binding Lectin / genetics*
  • Polymorphism, Genetic*
  • Proviruses / isolation & purification
  • Viral Load

Substances

  • Cytokines
  • Mannose-Binding Lectin