Dermatofibrosarcoma protuberans of breast

Cancer Genet Cytogenet. 2003 Apr 1;142(1):56-9. doi: 10.1016/s0165-4608(02)00844-0.

Abstract

We describe the case of a 57-year-old woman with a tumor of the breast suspected of being a dermatofibrosarcoma protuberans (DFSP). To confirm the diagnosis, molecular studies were performed on fixed tumor and revealed the presence of the fusion product of the COL1A1-PDGFB genes characteristic of DFSP.

Publication types

  • Case Reports

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / surgery
  • Collagen Type I / genetics
  • Collagen Type I, alpha 1 Chain
  • Dermatofibrosarcoma / genetics*
  • Dermatofibrosarcoma / pathology*
  • Dermatofibrosarcoma / surgery
  • Exons
  • Female
  • Humans
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics
  • Receptor, Platelet-Derived Growth Factor beta / genetics
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery

Substances

  • Collagen Type I
  • Collagen Type I, alpha 1 Chain
  • Oncogene Proteins, Fusion
  • Receptor, Platelet-Derived Growth Factor beta