Abstract
Although the genesis of invasive squamous cell carcinoma (SCC) from stratified epithelia of the skin is considered to be a complex, multistage process, recent work on human epidermis reveals that sustained Ras signaling coupled with suppression of Ras-induced growth arrest is sufficient to drive the entire process and that the alpha6beta4 integrin and its laminin 5 ligand are essential components of this process.
MeSH terms
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Animals
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Carcinoma / genetics*
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Carcinoma / pathology
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Genes, ras*
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Humans
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I-kappa B Kinase
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Integrin alpha6beta4 / metabolism*
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Laminin / metabolism
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Ligands
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Models, Biological
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NF-kappa B / antagonists & inhibitors
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NF-kappa B / genetics
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NF-kappa B / metabolism
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Neoplasm Invasiveness
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Neoplasms, Squamous Cell / genetics*
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Neoplasms, Squamous Cell / pathology
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Protein Serine-Threonine Kinases / metabolism
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Signal Transduction
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Skin Neoplasms / genetics*
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Skin Neoplasms / pathology
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ras Proteins / metabolism
Substances
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Integrin alpha6beta4
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Laminin
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Ligands
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NF-kappa B
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Protein Serine-Threonine Kinases
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CHUK protein, human
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I-kappa B Kinase
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IKBKB protein, human
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IKBKE protein, human
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ras Proteins