Abstract
The orphan nuclear receptor, Dax1, was originally proposed to act as an 'anti-testis' factor. We find, however, that Nr0b1 (also called Dax1 and Ahch, which encodes Dax1) is in fact required for testis differentiation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Crosses, Genetic
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DAX-1 Orphan Nuclear Receptor
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DNA-Binding Proteins / deficiency
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / physiology*
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Disorders of Sex Development
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Female
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Genes, sry
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Male
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Mice
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Mice, Knockout
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Muridae
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Receptors, Retinoic Acid / deficiency
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Receptors, Retinoic Acid / genetics*
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Receptors, Retinoic Acid / physiology*
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Repressor Proteins*
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Sex Differentiation / genetics*
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Sex Differentiation / physiology*
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Testis / embryology*
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Transcription Factors / deficiency
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Transcription Factors / genetics*
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Transcription Factors / physiology*
Substances
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DAX-1 Orphan Nuclear Receptor
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DNA-Binding Proteins
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Nr0b1 protein, mouse
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Receptors, Retinoic Acid
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Repressor Proteins
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Transcription Factors