Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia

Sharon P Mayer; Somasundaram Jayabose; Oya Tugal; M Fevzi Ozkaynak; Lynne Rosenblum-Vos; Claudio Sandoval

doi:10.1080/1042819021000006349a

Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia

Leuk Lymphoma. 2002 Sep;43(9):1881-4. doi: 10.1080/1042819021000006349a.

Authors

Sharon P Mayer¹, Somasundaram Jayabose, Oya Tugal, M Fevzi Ozkaynak, Lynne Rosenblum-Vos, Claudio Sandoval

Affiliation

¹ Department of Pediatric Hematology-Oncology, New York Medical College, Munger Pavillion, Rm 110, Valhalla, NY 10595, USA.

PMID: 12685849
DOI: 10.1080/1042819021000006349a

Abstract

We describe a case of relapsed pediatric pre-B acute lymphoblastic leukemia (ALL) with a simultaneous presentation of an intracerebral lymphoid mass. Cytogenetic, immunophenotypic and molecular analysis (immunoglobulin heavy chain and T-cell receptor gene rearrangements) revealed that the brain neoplasm was distinct from the relapsed leukemia. We discuss the etiology of this extremely rare event, and raise issues about the clonality of lymphoid neoplasms and the behavior of hematopoietic cells within the central nervous system (CNS).

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Central Nervous System Neoplasms / complications*
Central Nervous System Neoplasms / diagnosis*
Central Nervous System Neoplasms / genetics
Child
Cytogenetics
Female
Humans
Immunoglobulin Heavy Chains / genetics
Immunophenotyping
Molecular Sequence Data
Polymerase Chain Reaction
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Recurrence
Time Factors

Substances

Immunoglobulin Heavy Chains