Increased expression of c-maf in pure red cell aplasia secondary to plasma cell dyscrasia

Leuk Lymphoma. 2003 Mar;44(3):523-4. doi: 10.1080/1042819021000032890.

Abstract

Th2 dominancy in the peripheral T helper (Th) cell subsets were reported to be involved in the pathogenesis of pure red cell aplasia (PRCA). We encountered a PRCA case secondary to plasma cell dyscrasia that showed Th2 dominancy at the relapse of PRCA. Increased expression of c-maf, a transcriptional factor which induces Th2 differentiation of naive T-cells, and elevated expression of interleukin (IL)-4 were observed in the RNA derived from patient's bone marrow at relapse of PRCA. Following the administration of methylprednisolone which improved PRCA, normalization of Th1/Th2 ratio and decreased expression of c-maf and IL-4 were observed, which suggests that the upregulation of c-maf might have played a role in the pathogenesis of PRCA secondary to plasma cell dyscrasia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Marrow / metabolism
  • Cell Differentiation
  • DNA-Binding Proteins / biosynthesis*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation*
  • Humans
  • Immunoglobulin kappa-Chains / analysis
  • Immunoglobulin lambda-Chains / analysis
  • Immunosuppressive Agents / therapeutic use
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / genetics
  • Interleukin-4 / biosynthesis
  • Interleukin-4 / genetics
  • Interleukins / biosynthesis
  • Interleukins / genetics
  • Male
  • Methylprednisolone / therapeutic use
  • Paraproteinemias / complications*
  • Paraproteinemias / metabolism
  • Paraproteins / analysis
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-maf
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • Recurrence
  • Red-Cell Aplasia, Pure / drug therapy
  • Red-Cell Aplasia, Pure / etiology
  • Red-Cell Aplasia, Pure / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Th2 Cells / immunology
  • Thrombocytosis / etiology

Substances

  • DNA-Binding Proteins
  • Immunoglobulin kappa-Chains
  • Immunoglobulin lambda-Chains
  • Immunosuppressive Agents
  • Interleukins
  • MAF protein, human
  • Paraproteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-maf
  • RNA, Messenger
  • Interleukin-4
  • Interferon-gamma
  • Methylprednisolone