Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease

Mov Disord. 2003 May;18(5):593-5. doi: 10.1002/mds.10406.

Abstract

In a case control study, we examined the association of DRD2 Taq1A and Taq1B polymorphisms and risk of PD, and evaluated the strength of linkage disequilibrium of the polymorphisms. The Taq1A and Taq1B polymorphisms were in strong linkage disequilibrium. There was, however, no significant association of the two polymorphisms with PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Analysis of Variance
  • DNA Primers / genetics
  • Female
  • Gene Frequency / genetics
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Linkage Disequilibrium / genetics
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic / genetics*
  • Receptors, Dopamine D2 / genetics*
  • Taq Polymerase / classification
  • Taq Polymerase / genetics*

Substances

  • DNA Primers
  • Genetic Markers
  • Receptors, Dopamine D2
  • Taq Polymerase