Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer

Cancer Cell. 2003 Apr;3(4):307-10. doi: 10.1016/s1535-6108(03)00087-4.

Abstract

A recent paper in Cell (Fujita et al., 2003) demonstrates that MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, is an estrogen receptor-regulated inhibitor of the Snail zinc finger transcription factor in breast cancer. Given the important role of Snail in repressing E-cadherin transcription and the function of E-cadherin as a tumor suppressor protein and regulator of epithelial architecture, the findings offer potentially significant new insights into cancer pathogenesis.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • Cadherins / biosynthesis*
  • DNA-Binding Proteins / genetics
  • Female
  • Gene Expression Profiling
  • Gene Silencing
  • Humans
  • Mutation
  • Neoplasm Proteins / genetics
  • Receptors, Estrogen / physiology*
  • Signal Transduction
  • Snail Family Transcription Factors
  • Transcription Factors / genetics
  • Transcription, Genetic

Substances

  • Cadherins
  • DNA-Binding Proteins
  • MTA3 protein, human
  • Neoplasm Proteins
  • Receptors, Estrogen
  • Snail Family Transcription Factors
  • Transcription Factors