HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians

P Sanchez-Velasco; E Gomez-Casado; J Martinez-Laso; J Moscoso; J Zamora; E Lowy; C Silvera; A Cemborain; F Leyva-Cobián; A Arnaiz-Villena

doi:10.1034/j.1399-0039.2003.00041.x

HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians

Tissue Antigens. 2003 May;61(5):384-92. doi: 10.1034/j.1399-0039.2003.00041.x.

Authors

P Sanchez-Velasco¹, E Gomez-Casado, J Martinez-Laso, J Moscoso, J Zamora, E Lowy, C Silvera, A Cemborain, F Leyva-Cobián, A Arnaiz-Villena

Affiliation

¹ Department of Immunology and Molecular Biology, Hosp. 12 de Octubre, Universidad Complutense, Madrid, Spain.

PMID: 12753657
DOI: 10.1034/j.1399-0039.2003.00041.x

Abstract

HLA-A, -B, -DRB1, -DQA1 and -DQB1 alleles have been studied in three relatively isolated populations of northern Spain from Cantabria ( Pas Valleys inhabitants or Pasiegos and Cabuernigos) and from the Basque Country (Arratia Valley inhabitants). These populations have been compared with neighbouring ones and other Mediterraneans by using neighbour-joining dendrograms and plane genetic distances.

Publication types

Comparative Study
Historical Article
Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Emigration and Immigration
Ethnicity / genetics*
Gene Frequency
Genes, MHC Class I*
Genes, MHC Class II*
Genetics, Population*
HLA-A Antigens / genetics
HLA-B Antigens / genetics
HLA-DQ Antigens / genetics
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR Antigens / genetics
HLA-DRB1 Chains
Haplotypes / genetics
History, Ancient
Humans
Phylogeny
Polymorphism, Genetic
Spain

Substances

HLA-A Antigens
HLA-B Antigens
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DQA1 antigen
HLA-DQB1 antigen
HLA-DR Antigens
HLA-DRB1 Chains