Abstract
Interleukin-10 (IL-10) may have both pro- and anti-inflammatory effects in Guillain-Barré syndrome (GBS). The distribution of polymorphisms in the IL-10 gene (-1082 (G/A), -819 (T/C) and -592 (A/C)) was analysed to determine whether they could influence disease susceptibility or clinical course in GBS. The -592 CC and -819 CC genotypes associated with increased IL-10 response were more frequent in the GBS patients than in the controls (P=0.027), but the polymorphisms did not influence the clinical course of the disease.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
DNA Mutational Analysis
-
Female
-
Genetic Predisposition to Disease / genetics*
-
Genetic Testing
-
Genotype
-
Guillain-Barre Syndrome / genetics*
-
Guillain-Barre Syndrome / immunology
-
Guillain-Barre Syndrome / physiopathology
-
Haplotypes / genetics
-
Humans
-
Interleukin-10 / genetics*
-
Interleukin-10 / immunology
-
Male
-
Peripheral Nervous System / immunology*
-
Peripheral Nervous System / metabolism
-
Peripheral Nervous System / physiopathology
-
Polymorphism, Genetic / genetics*
-
Promoter Regions, Genetic / genetics*
-
Retrospective Studies