Arginase: marker, effector, or candidate gene for asthma?

J Clin Invest. 2003 Jun;111(12):1815-7. doi: 10.1172/JCI18908.

Abstract

Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Arginase / genetics*
  • Arginine / physiology
  • Asthma / enzymology*
  • Asthma / etiology
  • Asthma / genetics*
  • Gene Expression Profiling
  • Genetic Markers
  • Humans
  • Isoenzymes / genetics
  • Lung / enzymology
  • Mice
  • Nitric Oxide / physiology
  • Oligonucleotide Array Sequence Analysis

Substances

  • Genetic Markers
  • Isoenzymes
  • Nitric Oxide
  • Arginine
  • Arginase