Non-MHC-linked genes in autoimmune diseases

Curr Opin Immunol. 1992 Dec;4(6):716-22. doi: 10.1016/0952-7915(92)90051-f.

Abstract

The gene responsible for the lpr mutation in MRL mice that are prone to systemic lupus erythematosus has been shown to encode the apoptosis-inducing Fas antigen, thus pointing to control of apoptosis as a major regulatory mechanism in autoimmunity. In the non-obese diabetic mouse model for insulin-dependent diabetes, four non-MHC-linked loci have been localized in the murine genome that were found to be associated with successive stages of the disease. These findings should soon have a major impact on our understanding of human autoimmune diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Surface / genetics
  • Autoimmune Diseases / genetics*
  • Chromosome Mapping
  • Diabetes Mellitus, Type 1 / genetics
  • Genes, Immunoglobulin / immunology
  • Genetic Predisposition to Disease
  • Humans
  • Mice
  • Mice, Inbred NOD / genetics
  • Mice, Inbred NOD / immunology
  • Mice, Mutant Strains / genetics
  • Mice, Mutant Strains / immunology
  • Receptors, Antigen, T-Cell / genetics
  • fas Receptor

Substances

  • Antigens, Surface
  • Receptors, Antigen, T-Cell
  • fas Receptor