Augmentation of B7 expression by herpes simplex virus antigen

Hum Immunol. 2003 Aug;64(8):780-6. doi: 10.1016/s0198-8859(03)00103-4.

Abstract

B7 costimulation plays a major role in herpes simplex virus (HSV) immunity. Effects of immunoregulatory cytokines (interferon-gamma [IFN-gamma] and interleukin-10 [IL-10]) and HSV antigens on B7-1 (CD80) and B7-2 (CD86) expression on monocytes during HSV-2 infection were investigated using flow cytometry. Our results demonstrate that HSV-2 infection effects the expression of B7 isoforms (B7-1 and B7-2) on monocytes in two ways, with opposing outcomes. It abrogates the IFN-gamma upregulation of B7-1 and B7-2 and also augments expression of B7-1 and B7-2 on monocytes through an IFN-gamma independent mechanism. The clinical significance of these opposing effects may be related to the pathogenesis of recurrent HSV disease in immunocompetent hosts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / immunology*
  • Antigens, CD / metabolism*
  • Antigens, Viral / immunology*
  • B7-1 Antigen / immunology
  • B7-1 Antigen / metabolism*
  • B7-2 Antigen
  • Cells, Cultured
  • Flow Cytometry
  • Herpes Genitalis / immunology*
  • Herpes Genitalis / virology
  • Herpesvirus 1, Human / immunology
  • Herpesvirus 2, Human / immunology*
  • Humans
  • Interferon-gamma / immunology*
  • Interleukin-10 / immunology
  • Membrane Glycoproteins / immunology*
  • Membrane Glycoproteins / metabolism*
  • Models, Immunological
  • Monocytes / immunology*
  • Monocytes / virology
  • T-Lymphocytes / immunology
  • Up-Regulation

Substances

  • Antigens, CD
  • Antigens, Viral
  • B7-1 Antigen
  • B7-2 Antigen
  • CD86 protein, human
  • Membrane Glycoproteins
  • Interleukin-10
  • Interferon-gamma